In vivo imaging of oxidative stress and fronto-limbic white matter integrity in young adults with mood disorders

DF Hermens; SN Hatton; RSC Lee; SL Naismith; SL Duffy; G Paul Amminger; M Kaur; EM Scott; J Lagopoulos; IB Hickie

Journal article

In vivo imaging of oxidative stress and fronto-limbic white matter integrity in young adults with mood disorders

DF Hermens, SN Hatton, RSC Lee, SL Naismith, SL Duffy, G Paul Amminger, M Kaur, EM Scott, J Lagopoulos, IB Hickie

European Archives of Psychiatry and Clinical Neuroscience | SPRINGER HEIDELBERG | Published : 2018

DOI: 10.1007/s00406-017-0788-8

Abstract

Fronto-limbic connectivity is compromised in mood disorders, as reflected by impairments in white matter (WM) integrity revealed by diffusion tensor imaging. Although the underlying mechanisms remain unclear, disruption to normal myelination due to oxidative stress is thought to play a key role. We aimed to determine whether fronto-limbic WM integrity is compromised, and associated with in vivo antioxidant levels (indexed by glutathione; GSH), in young adults with unipolar depression (DEP) and bipolar (BD) disorders. Ninety-four patients with DEP, 76 with BD and 59 healthy controls (18–30 years) underwent diffusion tensor and proton magnetic resonance spectroscopy imaging. Fractional anisotr..

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University of Melbourne Researchers

Rico Lee Author

Paul Amminger Author

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Grants

Awarded by Eli Lilly and Company

Funding Acknowledgements

This study was supported by grants from the National Health & Medical Research Council (NHMRC) including: Centre of Research Excellence (No. 1061043), Australia Fellowship (No. 511921 awarded to IBH), Clinical Research Fellowship (No. 402864 awarded to SLN) and Senior Research Fellowship (No. 1080963 awarded to GPA). We would like to express our gratitude to individuals who participated in this study.